Computational
Biology
& Genomics

Bioinformatics researcher focused on pathogen genomics, metagenomics, sequencing workflows, epidemiology and computational biology.

Jigar Sheth

About

I am a Project Research Scientist (Bioinformatics) at Gujarat Biotechnology Research Centre (GBRC), India. My research combines microbial metagenomics, viral & bacterial genomics, and computational approaches to understand pathogen evolution, transmission dynamics, and host-pathogen interactions within the One Health framework.


I work extensively with long & short read sequencing datasets, developing scalable analytical workflows for metagenomics, microbial characterization, mutational profiling, and genome reconstruction.


Beyond bioinformatics, I enjoy exploring Gujarati literature, scouting new culinary ideas, and occasionally challenging the status quo.

Research Interests

Viral & Bacterial Genomics · Metagenomics · AI in Biology · Evolutionary Medicine

Pocket Tools

Python · R · Bash · Nextflow · Tensorflow · PyTorch

Research Focus

Viral & Bacterial Genomics

I am particularly fascinated by how viral and bacterial genomes continuously adapt across hosts, environments, and transmission networks, often leaving behind evolutionary and ecological signals that remain computationally underexplored.

Metagenomics

I am deeply interested in exploring what I often think of as the “metagenomic dark matter” — the vast amount of biological information hidden within large-scale sequencing datasets that remains computationally underexplored. My work focuses on developing computational and evolutionary approaches for genome-resolved metagenomics, s-level characterization, and pathogen surveillance. I am particularly interested in integrating Machine Learning, Artificial Intelligence, and evolutionary modeling to improve species detection, reduce false-positive identifications, and uncover hidden ecological and evolutionary patterns within microbial communities.

Sequencing Technology

Long-read tech is noisy. Designing computational frameworks for reducing sequencing noise and improving accuracy in long-read genomic data is in my to-do list.

AI & Computational Biology

Mathematics intrigues me! I think of integrating AI, mathematical modeling, and computational biology to develop large-scale frameworks for infectious disease prediction, outbreak modeling, and accurate identification of known and novel species from metagenomic datasets.

Projects

01

Zoonotic Surveillance & One-Health +

Building computational and metagenomic surveillance frameworks for monitoring zoonotic spillovers across environmental, animal, and human interfaces.

  • Analyzed Nanopore and Illumina metagenomic datasets
  • Identified viral co-infections of SARS-CoV-2 & Rhinovirus in clinical samples
  • Characterized ESBL and non-ESBL E.coli
  • Developed hybrid assembly workflows for bacteriophage characterization
Metagenomics
One Health
02

Epidemiological Mapping +

AES/AFI surveillance for epidemiological insights into prevalance of Chandipura virus in Gujarat, India

  • Taxonomic profiling of clinical & vector samples using Kraken2, GTDB-TK, GeNomad
  • Standarised workflow for retrieval of Metagenome-Assembled Genomes
Viromics
Phylogenomics
03

Single-cell & Machine Learning +

Machine learning approaches for transcriptomic profiling and tumor subtype classification.

  • Designed Random Forest model for tumor subtype classification from scRNA-Seq dataset
  • Identified non-coding RNA expressions in estrogen-response pathways in KAS-Seq and GRO-Seq datasets
scRNA-Seq
Machine Learning
Transcriptomics

Publications

Subtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology · 2024

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Structural insights into bedaquiline resistance associated mutations

Journal of Biomolecular Structure and Dynamics · 2023

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Designing multi-epitope based peptide vaccine targeting spike protein SARS-CoV-2 B1.1.529 (Omicron) variant using computational approaches⁠

Structural Chemistry · 2022

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Contact

If you've made it this far, I'd be glad to connect. Whether you're interested in collaborating in bioinformatics or computational biology, discussing research, or simply talking science — feel free to reach out.